Platelet-derived growth factor.

Abstract

Platelet-derived growth factor (PDGF) is emerging as a key mitogen in an increasing range of biological events, far more wide-reaching than initially suspected. Purification of the molecule and development of an antibody to PDGF have enhanced our ability to study its interactions with cells and the capacity of cells to express the gene for PDGF, secrete the molecule, and stimulate DNA synthesis and cell proliferation. The study of platelet-derived growth factor activity in normal biological processes and in disease processes has taken on many facets in a wide range of medical disciplines.