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PubMed · 3555814

Elective coronary surgery.

A M Chavez·B W Lytle·F D Loop
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Abstract

The goal of providing patent grafts distal to important coronary stenoses remains unchanged. Results of bypass grafting show the influence of refined technique, improved technology, and the longer followup now available. Coronary artery bypass is now routinely performed with low morbidity and mortality. Late attrition of saphenous vein grafts with concomitant deterioration of patients' clinical status has been increasingly recognized. The internal mammary graft, with its superior patency and impact on length and quality of survival, is gaining wider acceptance. Increased use of the mammary artery graft and extension of its use with bilateral and sequential grafting patterns are an important trend in the current practice of coronary surgery.

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Angina PectorisCoronary Artery BypassCoronary DiseaseGraft Occlusion, VascularHumansLongevityPostoperative ComplicationsRiskJournal ArticleReview

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BibTeXRIS

A M Chavez, B W Lytle, F D Loop. 1987. Elective coronary surgery.. https://pubmed.ncbi.nlm.nih.gov/3555814/

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Effect of a hypoglycemic agent on ischemic preconditioning in patients with type 2 diabetes and stable angina pectoris.

OBJECTIVE: Ischemic preconditioning is an increased tolerance to myocardial ischemia during the second of two consecutive exercise tests. ATP-sensitive K(+) channel blockers, such as glinides and sulfonylurea drugs, can induce loss of ischemic preconditioning. This study aimed to investigate the effects of repaglinide, a hypoglycemic agent with an affinity for myocardial ATP-sensitive K (+)channels, on the results of consecutive exercise tests in patients with diabetes and multivessel coronary artery disease. METHODS: Forty-two patients with type 2 diabetes and chronic stable angina pectoris, and two-vessel or three-vessel disease participated in this study. The patients underwent two consecutive treadmill exercise tests (phase 1). On the day after these exercise tests, 2 mg of oral repaglinide was given to the patients. One week later, two exercise tests were repeated consecutively (phase 2). RESULTS: All patients achieved 1.0-mm ST-segment depression during the four exercise tests (T1, T2, T3, and T4). In phase 2, seven patients improved in time to onset of 1.0-mm ST-segment depression. The worsening of the time to onset of 1.0-mm ST-segment depression in phase 2 demonstrated ischemic preconditioning block in 83.3% of patients (P=0.0001). Even the postexercise electrocardiographic parameters (ST-segment depression morphology and magnitude and arrhythmias) were significantly different between the groups with and without pharmacologic ischemic preconditioning block (P=0.031). CONCLUSIONS: Repaglinide, an oral hypoglycemic agent with ATP-sensitive K(+) channel-blocker activity, eliminated the myocardial ischemic preconditioning in patients with coronary disease and diabetes.

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