Carbohydrate interference of complement-dependent cell lysis.

J J Killion

doi:10.1007/bf01945571

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Carbohydrate interference of complement-dependent cell lysis.

J J Killion

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Abstract

The antibody-mediated cytotoxicity of three autoreactive sera, an allogeneic hyperimmune serum and a xenogeneic hyperimmune serum was abrogated by the presence of either glucosamine, galactosamine, lactulose or lactose. This inhibition could be overcome in a dose-dependent fashion by increasing the amount of complement in the cytotoxicity assay, but not by increasing the amount of antibody. Furthermore, the inhibition was specific for these sugars in that isomers and N-acetylated derivatives were not inhibitory. The results suggest that these sugars directly blocked events of the complement cascade.

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Animals Autoantibodies Carbohydrates Complement Inactivator Proteins Complement System Proteins Cytotoxicity, Immunologic Galactosamine Glucosamine Immune Sera Lactose Lactulose Mice Mice, Inbred C57BL Mice, Inbred DBA Mice, Inbred NZB Journal Article Research Support, Non-U.S. Gov't

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J J Killion. 1987-03-15. Carbohydrate interference of complement-dependent cell lysis.. https://doi.org/10.1007/bf01945571

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