Free energy calculations by computer simulation.

P A Bash; U C Singh; R Langridge; P A Kollman

doi:10.1126/science.3576184

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PubMed · 3576184

Free energy calculations by computer simulation.

P A Bash·U C Singh·R Langridge·P A Kollman

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Abstract

A fundamental problem in chemistry and biochemistry is understanding the role of solvation in determining molecular properties. Recent advances in statistical mechanical theory and molecular dynamics methodology can be used to solve this problem with the aid of supercomputers. By using these advances the free energies of solvation of all the chemical classes of amino acid side chains, four nucleic acid bases and other organic molecules can be calculated. The effect of a site-specific mutation on the stability of trypsin is predicted. The results are in good agreement with available experiments.

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Amino Acids Chemical Phenomena Chemistry, Physical Computer Simulation Hydrogen Bonding Models, Chemical Mutation Purines Pyrimidines Solvents Thermodynamics Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.

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P A Bash, U C Singh, R Langridge, P A Kollman. 1987-05-01. Free energy calculations by computer simulation.. https://doi.org/10.1126/science.3576184

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