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PubMed · 3601725

Acyclovir-associated fever: a case report.

B F Shea·M A Harbison·G P Sesin·P N Benotti·S M Hammer
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Abstract

Drug-induced fever has been associated with many agents. We treated a patient who developed high, spiking fevers while receiving intravenous acyclovir. Rechallenge with the drug was not attempted. Clinicians should be aware of the possibility of drug-induced fever in patients who receive systemic acyclovir.

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AcyclovirAdultBody TemperatureFemaleFeverHerpes SimplexHumansCase ReportsJournal Article

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B F Shea, M A Harbison, G P Sesin, P N Benotti, S M Hammer. 1987. Acyclovir-associated fever: a case report.. https://doi.org/10.1002/j.1875-9114.1987.tb03516.x

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Some new 6-amino-1,3-dimethyl-5-(substituted methylidene)aminouracils were synthesized. Most of them were cyclized with triethyl orthoformate as a one-carbon source to afford 1,3-dime-thyl-6-substituted pteridine derivatives. Certain uracils gave xanthine instead of the expected pteridine derivatives upon using another one-carbon source such as triethyl orthoacetate or triethyl orthobenzoate. The nucleic acid binding assay revealed that some new compounds showed high affinity, chelation, and fragmentation of nucleic acids whether DNA or RNA contrary to acyclovir that has affinity to DNA only. The antiviral activity of these novel compounds showed that compounds 2e and 2f reduced the cytopathogencity of Peste des petits ruminant virus (PPRV) on Vero cell culture by 60 and 50%, respectively.

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