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PubMed · 3602353

Radiation carcinogenesis: time-dose relationships.

R L Ullrich·M C Jernigan·L C Satterfield·N D Bowles
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Abstract

The present studies were undertaken to examine the time-dose relationships for the induction of lung adenocarcinomas and mammary adenocarcinomas in female BALB/c mice following gamma irradiation. Twelve-week-old female BALB/c/An NBd mice were irradiated with 137Cs gamma rays, and lifetime tumor incidences following high-dose-rate, low-dose-rate, or fractionated exposure regimens were compared. Analysis of the results indicated that the data could be fitted by linear-quadratic dose-response models for the induction of both tumors following acute doses and a linear model with a slope similar to that for the linear portion of the linear quadratic following low-dose-rate exposure regimens. When doses were fractionated the response was dependent upon the dose per fraction. If the dose per fraction was a dose which was predominantly on the linear portion of the acute dose response curve, then the response was linear and similar to that after low-dose-rate exposures. If the dose per fraction was in a region where the quadratic portion of the acute dose-response was significant, then the tumor incidence was higher than that following low-dose-rate exposures.

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AdenocarcinomaAnimalsDose-Response Relationship, RadiationFemaleGamma RaysLung NeoplasmsMammary Neoplasms, ExperimentalMiceMice, Inbred BALB CNeoplasms, Radiation-InducedRadiation DosageJournal ArticleResearch Support, U.S. Gov't, Non-P.H.S.

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R L Ullrich, M C Jernigan, L C Satterfield, N D Bowles. 1987. Radiation carcinogenesis: time-dose relationships.. https://pubmed.ncbi.nlm.nih.gov/3602353/

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