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PubMed · 3602590

pH modulates cisplatin toxicity.

A J Emonds·O M Driessen·R S Leeuwin·D de Vos
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Abstract

Cisplatin in normal saline of pH 2.5 caused haemolysis of rat erythrocytes, whereas cisplatin in normal saline of pH 3.5 did not. Even a difference of 0.2 pH units appeared to be of significant importance: haemolysis of rat erythrocytes was observed with cisplatin in saline of pH 3.0 but not with cisplatin in saline of pH 3.2. The LD in mice was 15.4 mg/kg for cisplatin in saline of pH 2.5 versus 24.0 mg/kg for cisplatin in saline of pH 3.5. Experiments with cisplatin should include careful control of pH.

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AnimalsCisplatinErythrocytesHemolysisHydrogen-Ion ConcentrationIn Vitro TechniquesLethal Dose 50MaleRatsRats, Inbred StrainsJournal Article

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A J Emonds, O M Driessen, R S Leeuwin, D de Vos. 1987. pH modulates cisplatin toxicity.. https://pubmed.ncbi.nlm.nih.gov/3602590/

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