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Clinical experiences with aclacinomycin-A.

H Furue·T Komita·I Nakao·I Furukawa·T Kanko·T Yokoyama
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Abstract

Aclacinomycin is a new anthracycline analog of adriamycin and daunomycin. Aclacinomycin contains three sugars. The drug has been studied in 22 cases in a phase 1 type of trial on a schedule 20 mg i.v. every other day up to a total of 300 mg. Toxicity has consisted of myelosuppression, nausea and vomiting, and transient hepatic disturbances. Evidence of clinical activity was observed in several cases including a case of breast cancer and gastric cancer. Although no full patial remissions were recorded, further study is continuing.

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AnimalsAntibiotics, AntineoplasticClinical Trials as TopicCricetinaeFemaleHumansLethal Dose 50MaleMiceMiddle AgedNaphthacenesNeoplasmsRatsClinical TrialJournal Article

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BibTeXRIS

H Furue, T Komita, I Nakao, I Furukawa, T Kanko, T Yokoyama. 1978. Clinical experiences with aclacinomycin-A.. https://doi.org/10.1007/978-3-642-81219-4_22

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