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Detecting behaviorally relevant changes in extracellular dopamine with microdialysis.

W H Church·J B Justice·D B Neill
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Abstract

A method is described for monitoring extracellular levels of striatal dopamine in the rat during behavior. The extracellular fluid is sampled using a microdialysis probe modified for use in behaving animals. Dopamine concentration in the perfusate is determined every 5 min using an automated smallbore chromatographic system with electrochemical detection. The system is capable of detecting behaviorally related changes of 5 nM, in extracellular dopamine.

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AnimalsBehavior, AnimalCorpus StriatumDopamineExtracellular SpaceFeeding BehaviorMaleRatsRats, Inbred StrainsJournal ArticleResearch Support, U.S. Gov't, Non-P.H.S.

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W H Church, J B Justice, D B Neill. 1987-06-02. Detecting behaviorally relevant changes in extracellular dopamine with microdialysis.. https://doi.org/10.1016/0006-8993(87)91150-4

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