PubMed · 36189
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C M Wai, C R Knowles, J F Keely. 1979. Lead caps on wine bottles and their potential problems.. https://doi.org/10.1007/bf01685376
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Liposomes of defined size and homogeneity have been prepared by sequential extrusion of the usual multilamellar vesicles through polycarbonate membranes. The process is easy, reproducible, produces no detectable degradation of the phospholipids, and can double the encapsulation efficiency of the liposome preparation. Multilamellar vesicles extruded by this technique are shown by both negative stain and freeze-fracture electron microscopy to have mean diameters approaching the pore diameter of the polycarbonate membrane through which they were extruded. When sequentially extruded down through a 0.2 micron membrane, the resulting vesicles exhibit a very homogeneous size distribution with a mean diameter of 0.27 micron while maintaining an acceptable level of encapsulation of the aqueous phase.
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The synthesis and characterization of a novel parenteral drug carrier capable of area specific localization by magnetic means are described. The carrier consists of human serum albumin microspheres, average of 1 micrometer in diameter, in which a magnetizable material (magnetite) and a prototype drug (doxorubicin) are entrapped. Stabilization of the microsphere matrix by formaldehyde, 2,3-butanedione, and heat conferred equal stability to the matrix but differentially affected the in vitro drug release rate. Release doxorubicin was chemically identical to the starting material.