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PubMed · 362907

Leukocyte alkaline phosphatase.

D B Okun·K R Tanaka
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Abstract

In summary, LAP is an intriguing enzyme and its control is related to pituitary-adrenal function. A review of the changes in LAP activity which occur in some physiological conditions and in disease states has been presented. The function of LAP, however, is unknown. Table I summarizes those conditions in which the LAP is consistently altered enough so to help in the diagnosis of the disorder. Of prime importance is the differentiation of CML from a leukemoid reaction or agnogenic myeloid metaplasia with a leukocytosis. However, in no instance is the LAP value alone diagnostic of any disease. It remains a laboratory test to be utilized in conjunction with all other available clinical data.

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Alkaline PhosphataseCell DifferentiationContraceptives, OralFemaleHistocytochemistryHumansLeukocytesMenstruationMethodsMyeloproliferative DisordersNeutrophilsPregnancyJournal ArticleResearch Support, U.S. Gov't, P.H.S.Review

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D B Okun, K R Tanaka. 1978. Leukocyte alkaline phosphatase.. https://doi.org/10.1002/ajh.2830040312

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