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Bayesian and least-squares methods for vancomycin dosing.

M Uaamnuichai·R B Day·D C Brater
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Abstract

The authors assessed the performance of a Bayesian and a least squares method for predicting individual pharmacokinetic parameters for vancomycin. For clearance, the best performance of both methods was an absolute error of approximately 5%. This level of accuracy required 4 serum vancomycin concentrations with the least squares method but could be achieved with a peak and trough concentration with the Bayesian method. For volume of distribution, the best performance occurred with 3 or 4 levels with both methods and amounted to an error of about 15%. In conclusion, both methods of estimating vancomycin pharmacokinetics perform comparably, but the Bayesian method appears to require fewer data.

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Bayes TheoremHumansKineticsMicrocomputersStatistics as TopicVancomycinJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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BibTeXRIS

M Uaamnuichai, R B Day, D C Brater. 1987. Bayesian and least-squares methods for vancomycin dosing.. https://doi.org/10.1097/00000441-198708000-00008

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