PubMed · 3636688
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M Wilson. 1986. Eating and drinking.. https://pubmed.ncbi.nlm.nih.gov/3636688/
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ain causes of failure and giving up in psychotropic lithiotherapics because of instable lithiemy to the same patient or functional acute renal insufficiency, are principaly mistaken diets, those mistaken concerning the amount, the quality and the way of taking drinking water and other beverages. Lithium salt, taken either in two times, morning and evening, or in one, must be absorbed at the end of a solid meal with at least 25 cl. of water. The patient must absorb at least 1.5 l. of water per day, and up to 3 l. in case of physical efforts or heat. The pH of this water and it ionic compound should be stable, as close as possible to the plasma's, without additives that could change its taste. This includes cooking water and infusions. Physicopharmacological explanations.
1. The present study was performed to examine the effect of naloxone on drinking behavior in three schizophrenic inpatients with psychosis, intermittent hyponatremia, and polydipsia. 2. Their body weight were checked five times daily and the maximum weight gain during a day was chosen as an index of their polydipsia. 3. After control recording for six weeks, a daily naloxone (0.6 mg) injection series was performed once every two weeks for three series (six weeks). Withdrawal of this drug for six weeks resulted in weight gain recovering to control level. 4. The present study showed that naloxone seems to be a potential treatment for psychiatric patients displaying self-induced water intoxication and that endogenous opioid systems are involved in the compulsive drinking behavior of this syndrome.
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