Uncharged tRNA error damping model.

J A Gallant

doi:10.1016/0014-5793(86)80977-2

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Uncharged tRNA error damping model.

J A Gallant

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Abstract

Uncharged tRNA is known to bind to the ribosome in a codon-specific fashion. In this way, cognate uncharged tRNA competes with non-cognate aminoacyl-tRNA. If uncharged tRNA can be aminoacylated while on the ribosome, this will damp errors due to aminoacyl-tRNA imbalance. Kinetic analysis shows that this scheme reduces errors at 'hungry' codons considerably more effectively than J. Ninio's accuracy tuner model; for example, a 10-fold decrease in cognate aminoacyl-tRNA elicits only a 10% increase in the error frequency.

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Binding, Competitive Codon Kinetics Models, Biological Mutation Peptidyl Transferases Protein Biosynthesis RNA, Messenger RNA, Transfer RNA, Transfer, Amino Acyl Ribosomes Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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J A Gallant. 1986-10-06. Uncharged tRNA error damping model.. https://doi.org/10.1016/0014-5793(86)80977-2

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