Mice genetically selected for differences in open-field activity after ethanol.

J C Crabbe; E R Young; C M Deutsch; B R Tam; A Kosobud

doi:10.1016/0091-3057(87)90371-6

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Mice genetically selected for differences in open-field activity after ethanol.

J C Crabbe·E R Young·C M Deutsch·B R Tam·A Kosobud

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Abstract

Starting from a population of genetically heterogeneous mice, selective breeding is being used to develop lines differing in sensitivity to ethanol-induced open-field activity. Mice are tested twice for 4 min in an open field. The first test is between min 2-6 after injection of saline. Twenty-four hr later, a similar test is performed after injection of ethanol (1.5 g/kg). Two independent FAST lines are being selected for ethanol-induced increases in activity, and two independent SLOW lines are being selected for ethanol-induced decreases. After four generations of selection, the lines have diverged significantly. These lines should be useful for exploring the neuropharmacological basis for the activating and rewarding properties of ethanol.

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Animals Breeding Ethanol Female Genetics, Behavioral Male Mice Motor Activity Journal Article Research Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.

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J C Crabbe, E R Young, C M Deutsch, B R Tam, A Kosobud. 1987. Mice genetically selected for differences in open-field activity after ethanol.. https://doi.org/10.1016/0091-3057(87)90371-6

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