Endotoxin: a twofold effect on bone marrow ultrastructure.

T Hirahata; D Bjorkman; J K Chamberlain

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PubMed · 3659866

Endotoxin: a twofold effect on bone marrow ultrastructure.

T Hirahata·D Bjorkman·J K Chamberlain

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Abstract

Ultrastructural studies of mouse bone marrow reveal that reduction of the marrow-blood barrier precedes the two waves of leukocytosis which follow endotoxin administration. These ultrastructural changes include a decrease in adventitial cover of the marrow sinus wall, an increase in sinus circumference, and a decrease in endothelial cell overlap. The marrow-blood barrier changes which precede the first wave of leukocytosis are transient and are associated with depletion of marrow granulocytes. The changes that precede the second wave of leukocytosis 5 to 6 days later are more sustained and are associated with marked granulocyte hyperplasia. We suggest that endotoxin has two effects on marrow ultrastructure: (1) an early, direct effect on the sinus wall and (2) a later, indirect effect associated with granulocyte proliferation. The late effect may be mediated through endotoxin induced release of colony stimulating factor. Both effects diminish the normal marrow-blood barrier and appear to facilitate cell release from the marrow.

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Animals Bone Marrow Endothelium Endotoxins Female Hematopoiesis Mice Microscopy, Electron Journal Article

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T Hirahata, D Bjorkman, J K Chamberlain. 1987. Endotoxin: a twofold effect on bone marrow ultrastructure.. https://pubmed.ncbi.nlm.nih.gov/3659866/

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