n-3 Essential fatty acids decrease weight gain in genetically obese mice.

S C Cunnane; K R McAdoo; D F Horrobin

doi:10.1079/bjn19860088

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n-3 Essential fatty acids decrease weight gain in genetically obese mice.

S C Cunnane·K R McAdoo·D F Horrobin

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Abstract

1. Lean (ln/ln) and obese (ob/ob) mice were given diets containing a fat source of 100 g evening primrose (Oenothera biennis) oil (fatty acids 18:2n-6, 18:3n-6; EPO) or 100 g cod liver oil (20:5n-3, 22:6n-3; CLO)/kg diet. 2. Weight gain was lower in the ob/ob mice fed on CLO, an effect unrelated to food intake. 3. In the ob/ob mice fed on CLO, thromboxane synthesis by clotting platelets was reduced compared with that in ob/ob mice fed on EPO. 4. The ob/ob CLO-fed mice had lower arachidonic acid but higher levels of n-3 fatty acids in liver, brown adipose tissue and white adipose tissue. 5. The n-3 fatty acids in CLO therefore replaced the n-6 fatty acids in tissue lipids and reduced synthesis of '2 series' prostaglandins in addition to causing lower weight gain in the CLO-fed ob/ob mice.

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Animals Body Weight Fatty Acids Fatty Acids, Essential Lipids Male Mice Mice, Inbred C57BL Obesity Phospholipids Thromboxane B2 Journal Article Research Support, Non-U.S. Gov't

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S C Cunnane, K R McAdoo, D F Horrobin. 1986. n-3 Essential fatty acids decrease weight gain in genetically obese mice.. https://doi.org/10.1079/bjn19860088

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