Species correlation in long-term carcinogenicity studies.

J K Haseman; J E Huff

doi:10.1016/0304-3835(87)90154-6

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Species correlation in long-term carcinogenicity studies.

J K Haseman·J E Huff

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Abstract

Species correlation in neoplastic response was examined for 266 long-term toxicology and carcinogenicity studies. The overall concordance between rats and mice exposed to the same chemical was 74% (198/266). Within a species, the results for males and females were also highly correlated (87% concordance for rats and 89% for mice). Had only male rats and female mice been utilized in these experiments, the same conclusions regarding carcinogenicity would have been reached in 96% of the studies (255/266). The high interspecies correlation shown in these studies supports the view that extrapolation of carcinogenicity outcomes to other species, including humans, is appropriate.

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Animals Female Male Mice Neoplasms, Experimental Rats Sex Factors Species Specificity Journal Article

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J K Haseman, J E Huff. 1987-10-30. Species correlation in long-term carcinogenicity studies.. https://doi.org/10.1016/0304-3835(87)90154-6

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