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Multi-centre versus single-centre trials in migraine.

C Hedman·A R Andersen·J Olesen
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Abstract

Migraine trials often have to be performed at many centres, which creates a number of methodological problems. The present paper discusses single-centre versus multi-centre designs and also comments on the design of multiple-independent trials (MIT). From a methodological standpoint, the single-centre design should virtually always be preferred. When it is impossible to recruit enough patients in a single centre within reasonable time, a multi-centre design has to be used. The major advantage of multi-centre trials, apart from recruitment, is that they may yield a more representative basis for conclusions regarding the whole population. Multiple-independent trials give an opportunity to summarize information from different sources. It has not the same methodological strength as the single- or multi-centre trial, but could be valuable, especially for evaluation of side effects.

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Clinical Trials as TopicHumansMigraine DisordersJournal Article

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BibTeXRIS

C Hedman, A R Andersen, J Olesen. 1987. Multi-centre versus single-centre trials in migraine.. https://doi.org/10.1159/000110119

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