PubMed · 368439
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J R de la Fuente, A H Rosenbaum. 1979. Psychoendocrinology.. https://pubmed.ncbi.nlm.nih.gov/368439/
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The aim of this study was to test predictions based on Grossberg's theories of overarousal in neural networks as related to schizophrenic symptomatology. We predicted that symptoms of blunted affect and volition would be associated with reduced P300 amplitude, while impaired attention and short-term memory and symptoms of disorganization would be associated with increased N200 and P300 latency. Event-related potentials, elicited by auditory stimuli, were recorded in 20 chronic schizophrenic men on neuroleptic medication and an age- and sex-matched control group of 20 normal volunteers. The amplitude and latency values of the N200 and P300 waves at the vertex (Cz) were compared with clinical ratings (the Scale for the Assessment of Positive Symptoms and the Scale for the Assessment of Negative Symptoms) and with neuropsychological test scores by means of Spearman rank correlation coefficient. The patients showed a reduced P300 amplitude and an increased N200 latency. No correlation was found between the P300 amplitude and the symptom scores. The N200 latency was negatively correlated with auditory digit span and positively correlated with high global scores for attentional impairment, alogia, and positive formal thought disorder. Our initial predictions are partly confirmed by the apparent association between increased N200 latency and symptoms of disorganization.
BACKGROUND: Federal regulations require states to estimate the prevalence and incidence of serious emotional disturbance (SED) in children, defined as a DSM-III-R diagnosis in the presence of impaired functioning in 1 or more areas. We reviewed the published data on SED and examined rates and correlates of SED in an ongoing epidemiologic study of children. METHODS: Rates of DSM-III-R disorders, functional impairment, and their co-occurrence (SED) were examined in a representative population sample of 9-, 11-, and 13-year-olds from a predominantly rural area of North Carolina. Three measures of functional impairment were used, and their interrelationship and impact on rates of SED were examined. RESULTS: Serious emotional disturbance was identified in 4% to 8% of the study population, depending on the measure of impairment; the rate of DSM-III-R disorder ignoring impairment was 20.3%. One quarter of children identified as having SED on any measure were identified by all 3, and one half by 2 or more. Behavioral disorders, emotional disorders, and comorbidity were associated with a significant increase in the likelihood of SED; enuresis and tic disorders in the absence of comorbidity were not. Diagnosis and impairment made independent contributions to the increase in service use seen in children with SED. Poverty greatly increased the likelihood of SED. CONCLUSIONS: Specific areas of functional impairment should be examined when SED is assessed and treatment is planned. Plans to target mental health care resources to children with SED need to be accompanied by efforts to ensure access to those resources.
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