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PubMed · 3715892

Dehydroascorbic acid and cell membranes: possible disruptive effects.

J Bianchi·R C Rose
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Abstract

Exposure of cellular membranes to dehydroascorbic acid can result in a loss of membrane integrity. Renal brush border or basolateral membrane vesicles pre-incubated with dehydroascorbic acid demonstrate a decrease in initial transport rates of D-glucose and a loss of intravesicular volume. The activity of brush border membrane specific leucine aminopeptidase is increased in vesiculated membrane preparations following exposure of the vesicles to either dehydroascorbic acid or Triton X-100. Erythrocytes in isotonic buffer with dehydroascorbic acid lose membrane integrity as demonstrated by a release of hemoglobin.

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AnimalsBiological TransportCell MembraneDehydroascorbic AcidErythrocyte MembraneGlucoseHumansIn Vitro TechniquesKidney Tubules, ProximalLeucyl AminopeptidaseMicrovilliOctoxynolPolyethylene GlycolsRatsJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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J Bianchi, R C Rose. 1986. Dehydroascorbic acid and cell membranes: possible disruptive effects.. https://doi.org/10.1016/0300-483x(86)90047-8

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