Poly(iminocarbonates) as potential biomaterials.

J Kohn; R Langer

doi:10.1016/0142-9612(86)90098-0

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Poly(iminocarbonates) as potential biomaterials.

J Kohn·R Langer

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Abstract

Poly(iminocarbonates), based on diphenols such as hydroquinone or Bisphenol A were synthesized. Poly(iminocarbonates) degraded under physiological conditions. Compression moulded discs of poly-(hydroquinone-iminocarbonate) showed near zero-order release for low loadings (1%, w/w) of Eosin Y. Poly(Bisphenol A-iminocarbonate) formed transparent films and strong fibres. It is a tough polymer with high tensile strength. Under physiological conditions complete erosion of a thin film of poly(Bisphenol A-iminocarbonate) required about 200 d. The release profile for p-nitroaniline from solvent cast films of poly(Bisphenol A-iminocarbonate) was characterized by a lag period (20 d), followed by near zero-order release for 90 d. Initial toxicological studies revealed no inflammatory cell response after implantation in the corneas of rabbits or subcutaneously in mice.

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Animals Biocompatible Materials Biodegradation, Environmental Carbonates Connective Tissue Cornea Hydrolysis Imines Male Mice Molecular Weight Polymers Prostheses and Implants Rabbits Tensile Strength Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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J Kohn, R Langer. 1986. Poly(iminocarbonates) as potential biomaterials.. https://doi.org/10.1016/0142-9612(86)90098-0

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