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PubMed · 3730535

DNA structural variability as a factor in gene expression and evolution.

M Conrad·S K Brahmachari·V Sasisekharan
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Abstract

Redundant DNA can buffer sequence dependent structural deviations from an ideal double helix. Buffering serves a mechanistic function by reducing extraneous conformational effects which could interfere with readout or which would impose energetic constraints on evolution. It also serves an evolutionary function by allowing for gradual variations in conformation-dependent regulation of gene expression. Such gradualism is critical for the rate of evolution. The buffer structure concept provides a new interpretation for repetitive DNA and for exons and introns.

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Base SequenceBiological EvolutionDNAGene Expression RegulationModels, GeneticNucleic Acid ConformationRepetitive Sequences, Nucleic AcidJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, Non-P.H.S.

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M Conrad, S K Brahmachari, V Sasisekharan. 1986. DNA structural variability as a factor in gene expression and evolution.. https://doi.org/10.1016/0303-2647(86)90024-9

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