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Central auditory function in a hearing-impaired white mouse.

K C Horner·C Barkway
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Abstract

The dysfunction of the stria vascularis in the viable dominant spotting mutant mouse results in the reduction or the absence of the endocochlear potential. However, these mutants respond to an intense acoustic stimulus with a Preyer reflex (pinna twitch). This study used 14C autoradiography and electromyography to investigate central auditory responses in this mutant. There were three main findings: autoradiography demonstrated an increase in the metabolic rate within each of the central auditory nuclei during noise exposure compared with silence; electromyographic recordings indicated that there was no tensor tympani muscle reflex; the mutants were found to be susceptible to audiogenic seizures. It was concluded that the central auditory pathway of the viable dominant spotting mutant could be activated despite the abnormal strial function. Absence of the tensor tympani muscle reflex, together with auditory deprivation, might contribute to the susceptibility to audiogenic seizures.

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Acoustic StimulationAnimalsAuditory PathwaysCochleaHearing DisordersLabyrinth DiseasesMiceReflex, AbnormalSeizuresTensor TympaniTympanic MembraneJournal Article

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K C Horner, C Barkway. 1986. Central auditory function in a hearing-impaired white mouse.. https://doi.org/10.1016/0378-5955(86)90176-0

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