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Soluble fibrinogen derivatives generated by thrombin: affinity for elastin.

M Rabaud·F Lefebvre·Y Piquet·F Belloc·J Chevaleyre·M F Roudaut·H Bricaud
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Abstract

When human citrated plasma is dialysed against a phosphate buffer containing Ca++, citrate anions are removed, thrombin is generated and soluble fibrinogen derivatives (fibrin monomers and/or soluble fibrin polymers) are formed. These derivatives are able to combine with human or bovine elastin to form a very stable addition product or adduct. The formation of the adduct is dependent on time, Ca++ and thrombin concentrations.

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AnimalsArteriosclerosisCalciumCattleCitratesCitric AcidDialysisElastinFibrinogenHumansIn Vitro TechniquesSolubilityThrombinThrombosisJournal ArticleResearch Support, Non-U.S. Gov't

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M Rabaud, F Lefebvre, Y Piquet, F Belloc, J Chevaleyre, M F Roudaut, H Bricaud. 1986-07-15. Soluble fibrinogen derivatives generated by thrombin: affinity for elastin.. https://doi.org/10.1016/0049-3848(86)90061-7

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