Gene networks in development.

E R Jackson; D Johnson; W G Nash

doi:10.1016/s0022-5193(86)80190-4

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Gene networks in development.

E R Jackson·D Johnson·W G Nash

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Abstract

A model is presented for the formation of temporal and spatial patterns of cell types during the development of organisms. It is demonstrated that very simple random networks of interactions among genes that affect expression may lead to the autonomous development of patterns of cell types. It is required that the networks contain active feedback loops and that there is limited communication among cells. The only elements of the model, gene interactions, are specified by the DNA nucleotide sequences of the genes. Therefore, the model readily explains how the control of development is specified by the organism's DNA. In the context of this model, the formation of positional information and its interpretation becomes a single process.

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Biological Evolution Cell Cycle Gene Expression Regulation Genes Models, Genetic Morphogenesis Protein Biosynthesis Journal Article Research Support, Non-U.S. Gov't

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E R Jackson, D Johnson, W G Nash. 1986-04-21. Gene networks in development.. https://doi.org/10.1016/s0022-5193(86)80190-4

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