A test bed for ocular drugs.

C Wigham; S Hodson

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PubMed · 3748559

A test bed for ocular drugs.

C Wigham·S Hodson

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Abstract

Corneal endothelium plays a vital role in maintaining corneal transparency. We describe here a new in vitro technique for detecting acute effects of ocular drugs on corneal endothelium from animal species and post-mortem human tissue. The technique is based upon trans-endothelial electrical activity and leads as a consequence, to rapid, unambiguous, quantitative assessments of pharmacological effects upon endothelial barrier function and fluid pump activity.

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Animals Carbonic Anhydrase Inhibitors Chymotrypsin Cornea Drug Evaluation, Preclinical Endothelium Epinephrine Ethanol Humans In Vitro Techniques Ouabain Rabbits Time Factors Journal Article Research Support, Non-U.S. Gov't

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C Wigham, S Hodson. 1986. A test bed for ocular drugs.. https://pubmed.ncbi.nlm.nih.gov/3748559/

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