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Verapamil does not antagonize LSD-induced stimulus control.

J C Winter
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Abstract

Discriminative stimulus control was established in rats (N = 6) with LSD (100 microg/kg) and saline using a 2-lever response choice task and an FR10 schedule of food reinforcement. Subjects were then tested once per week with either pizotyline (BC-105) or verapamil alone or in combinations with LSD. In In agreement with previous reports, pizotyline antagonized LSD and, when tested alone, exhibited modest agonistic effects (18% LSD-appropriate). In contrast, verapamil failed to block LSD at any dose tested. Verapamil alone appeared to have somewhat greater agonistic activity (35% LSD-appropriate) than did pizotyline but neither drug substituted completely for LSD. These data suggest that calcium channel antagonism by pizotyline is not essential to its anti-LSD effects.

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AnimalsConditioning, OperantDiscrimination LearningFoodLysergic Acid DiethylamideMalePizotylineRatsRats, Inbred F344ThiophenesVerapamilComparative StudyJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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J C Winter. 1986. Verapamil does not antagonize LSD-induced stimulus control.. https://doi.org/10.1016/0091-3057(86)90258-3

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