Inbreeding and the balance between selection and mutation.

Abstract

The first half of the paper described the structure of a large population caused by subdivision and inbreeding. Then, in the second half, it shows the structure of a population does not play any role in determining the incidence of the recessive genotype (aa). The latter is determined entirely by the ratio of the mutation rate to the selection coefficient. The recessive gene frequency, however, depends much on the structure of the population. The effect of relaxing inbreeding and subdivision on the rise and fall (rather the fall and rise) of the recessive gene frequency has been discussed.