Compounds that inhibit chymotrypsin and cell replication.

B Goz; C Ganguli; M Troconis; S Wyrick; K S Ishaq; J A Katzenellenbogen

doi:10.1016/0006-2952(86)90630-1

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Compounds that inhibit chymotrypsin and cell replication.

B Goz·C Ganguli·M Troconis·S Wyrick·K S Ishaq·J A Katzenellenbogen

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Abstract

Several compounds have been tested for their ability to inhibit bovine pancreatic alpha-chymotrypsin (Ki) and their ability to inhibit cell replication (IC50). There is good agreement over three orders of magnitude between the Ki and the IC50 values of these compounds. The data support the hypothesis that a cellular, chymotrypsin-like activity is necessary for cell replication.

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Animals Boronic Acids Cattle Cell Division Cell Line Chymotrypsin Kinetics Mice Pancreas Protease Inhibitors Structure-Activity Relationship Journal Article Research Support, U.S. Gov't, P.H.S.

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B Goz, C Ganguli, M Troconis, S Wyrick, K S Ishaq, J A Katzenellenbogen. 1986-10-15. Compounds that inhibit chymotrypsin and cell replication.. https://doi.org/10.1016/0006-2952(86)90630-1

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