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PubMed · 3775600

Immunoreactive digitalis-like substance in pre-eclampsia.

H J Odendaal·A D Beyers·C F van Heyningen·L L Spruyt·T J Kotze·P P van Jaarsveld
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Abstract

An endogenous digitalis-like substance (DLS) may be involved in the pathogenesis of essential hypertension and pre-eclampsia. The digoxin levels in maternal and cord blood of 504 randomly selected patients were determined. Since none of the patients received digoxin, these levels indicated a cross-reacting substance (immunoreactive DLS). DLS levels were significantly higher in the cord blood of pre-eclamptic patients than in the cord blood of controls. DLS levels in cord blood increased with the severity of pre-eclampsia, and levels were higher in primigravidas than in multigravidas. The structure and biological activity of DLS must be determined before definite conclusions about its role in the pathogenesis of pre-eclampsia can be made.

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Digitalis GlycosidesDigoxinFemaleFetal BloodHumansPre-EclampsiaPregnancyJournal Article

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BibTeXRIS

H J Odendaal, A D Beyers, C F van Heyningen, L L Spruyt, T J Kotze, P P van Jaarsveld. 1986-10-25. Immunoreactive digitalis-like substance in pre-eclampsia.. https://pubmed.ncbi.nlm.nih.gov/3775600/

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