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Two-disease locus model: sib pair method using information on both HLA and Gm.

M H Dizier·F Clerget-Darpoux
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Abstract

An adaptation of the sib pair method is given for testing the independence of transmission of Gm and the disease, using variable X (which gives information on the phenotypic identity of a sib pair for Gm). Then the joint distribution of IBD for HLA and X for Gm among affected sib pairs was derived under different two-locus models (multiplicative and other) in which one locus is strictly linked to HLA and the other to Gm. We also propose a test for a joint effect of HLA and Gm and whether this effect is multiplicative or not.

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Genetic Diseases, InbornHLA AntigensHumansImmunoglobulin AllotypesModels, GeneticPhenotypePolymorphism, GeneticProbabilityJournal Article

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M H Dizier, F Clerget-Darpoux. 1986. Two-disease locus model: sib pair method using information on both HLA and Gm.. https://doi.org/10.1002/gepi.1370030507

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