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A complement receptor locus: genes encoding C3b/C4b receptor and C3d/Epstein-Barr virus receptor map to 1q32.

J H Weis·C C Morton·G A Bruns·J J Weis·L B Klickstein·W W Wong·D T Fearon
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Abstract

The alternative or classical pathways for complement system component C3 may be triggered by microorganisms and antigen-antibody complexes. In particular, an activated fragment of C3, C3b, covalently attaches to microorganisms or antigen-antibody complexes, which in turn bind to the C3b receptor, also known as complement receptor 1. The genes encoding the proteins that constitute the C3-activating enzymes have been cloned and mapped to a "complement activation" locus in the major histocompatibility complex, and we demonstrate in this study such a locus on the long arm of chromosome 1 at band 1q32.

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Chromosome MappingChromosomes, Human, Pair 1GenesHumansNucleic Acid HybridizationReceptors, ComplementJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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J H Weis, C C Morton, G A Bruns, J J Weis, L B Klickstein, W W Wong, D T Fearon. 1987-01-01. A complement receptor locus: genes encoding C3b/C4b receptor and C3d/Epstein-Barr virus receptor map to 1q32.. https://pubmed.ncbi.nlm.nih.gov/3782802/

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