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Reticuloendothelial system phagocytic function in obstructive jaundice and its modification by a muramyl dipeptide analogue.

J A Pain·D S Collier·A Ritson
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Abstract

Measurement of reticulo-endothelial system (RES) phagocytic function by clearance of intravenous micro-aggregated human albumin (HMAA) showed prolonged clearance in both patients (p less than 0.001) and rats (p less than 0.001) with extrahepatic biliary tract obstruction compared with non-jaundiced controls. After the administration of the immune stimulator, N-acetyl-L-alpha-aminobutyryl-D-isoglutamine, the mean HMAA clearance rate in jaundiced animals was similar to that of non-jaundiced controls. The implications of modifying RES phagocytic function to prevent overspill of endotoxins from the portal to systemic circulation in obstructive jaundice are discussed.

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Acetylmuramyl-Alanyl-IsoglutamineAgedAlbuminsAnimalsCholestasisHumansMetabolic Clearance RateMononuclear Phagocyte SystemPhagocytosisRatsTissue DistributionJournal ArticleResearch Support, Non-U.S. Gov't

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J A Pain, D S Collier, A Ritson. 1987. Reticuloendothelial system phagocytic function in obstructive jaundice and its modification by a muramyl dipeptide analogue.. https://doi.org/10.1159/000128676

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Acetylmuramyl-Alanyl-Isoglutamine↗
PubMed2007

NOD protein expression and function in first trimester trophoblast cells.

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