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An improved nuclear magnetic resonance diffusion coefficient imaging method using an optimized pulse sequence.

C B Ahn·S Y Lee·O Nalcioglu·Z H Cho
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Abstract

Two-dimensional diffusion coefficient maps (images) of a carefully controlled diffusion phantom have been measured by a new diffusion imaging sequence using a 0.6-T whole-body nuclear magnetic resonance (NMR) scanner having a gradient field strength of 2.5 mT/m. The free induction decay (FID) data for the diffusion coefficient images were collected by varying the duration of the readout gradient in the conventional two-dimensional Fourier imaging sequence. The experimental results obtained by the proposed NMR diffusion measurement technique indicate a close agreement with other previous measurements. The selection of optimum spin-echo time for maximum signal-to-noise ratio (SNR) in diffusion imaging is studied and also experimentally confirmed. Finally, a preclinical study with human volunteers has been performed and results are presented.

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HumansMagnetic Resonance SpectroscopyModels, StructuralJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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C B Ahn, S Y Lee, O Nalcioglu, Z H Cho. An improved nuclear magnetic resonance diffusion coefficient imaging method using an optimized pulse sequence.. https://doi.org/10.1118/1.595850

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