Dietary restriction retards age-related decrease in cell population of rat corneal endothelium.

M J Nadakavukaren; K L Fitch; A Richardson

doi:10.3181/00379727-184-42451

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Dietary restriction retards age-related decrease in cell population of rat corneal endothelium.

M J Nadakavukaren·K L Fitch·A Richardson

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Abstract

The surface areas of corneal endothelial cells from 12- and 18-month-old male Fischer 344 rats fed ad libitum or a calorie-restricted diet were compared. The rats fed the restricted diet in both age groups showed a statistically significant reduction in the mean cell area of the corneal endothelium. The data indicate that dietary restriction retarded the age-related endothelial cell loss and the subsequent enlargement that takes place to compensate for cell loss. This is the first report to suggest that dietary restriction retards age-related cell loss.

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Aging Animals Cornea Diet Endothelium Energy Intake Male Rats Journal Article Research Support, U.S. Gov't, P.H.S.

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M J Nadakavukaren, K L Fitch, A Richardson. 1987. Dietary restriction retards age-related decrease in cell population of rat corneal endothelium.. https://doi.org/10.3181/00379727-184-42451

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