[The cold thyroid nodule].

H D Röher; P Goretzki

doi:10.1007/bf01274350

Home/Archive/PubMed

PubMed · 3807517

[The cold thyroid nodule].

H D Röher·P Goretzki

View original source ↗Export metadata ↓

Abstract

A "cold" thyroid nodule basically always carries the risk of being "malignant". Scintigraphy and sonography can not differentiate between benign and malignant. The best means to discriminate the risk of "cold nodules" is by way of fine needle aspiration biopsy. In general the operative indication for "cold" nodules can be generous. In high suspicion the best surgical strategy is "hemithyroidectomy" as primary operation.

Explore related subjects

Biopsy, Needle Diagnosis, Differential Humans Thyroid Diseases Thyroid Gland Thyroid Neoplasms English Abstract Journal Article

Keep this discovery

Explore connections, maps & timelines

BibTeX RIS

H D Röher, P Goretzki. 1986. [The cold thyroid nodule].. https://doi.org/10.1007/bf01274350

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed1996

[Preoperative needle biopsy: an improvement in palpable breast tumors with strong indications for malignancy].

OBJECTIVE: To assess the value of needle core biopsy to replace frozen sections in palpable breast masses highly suspicious for malignancy. DESIGN: Cohort study. SETTING: University Hospital Leiden, the Netherlands. METHOD: In 274 patients with 279 palpable breast masses a needle core biopsy was performed in addition to the triple diagnostic approach (i.e. physical examination, imaging by mammography and ultrasound and cytologic examination), if highly suspicious for malignancy. The core biopsy was performed by means of a 18-gauge needle in 89 lesions guided by palpation and in 190 lesions under ultrasound guidance. The results were compared with the final diagnosis: 19 benign lesions and 260 malignant lesions. RESULTS: In 63 lesions the results of the triple diagnostic approach were unequivocally malignant, this was confirmed in all cases. In 208 lesions the results of the needle core biopsy were malignant, without false positive results. However, there were 3 false negative results. The proportion of inconclusive needle core biopsies was higher when performed on palpation (35%) than when performed under ultrasound guidance (7%). When the specimen showed non-invasive carcinoma, a reliable prediction of invasion was not possible. In 264 cases excision of the lesion was performed. Given the unequivocally malignant triple diagnostic approach in 59 cases of the 264 patients operated (22%) frozen sections were not performed. By addition of needle core biopsy this percentage rose to 74%. CONCLUSION: Needle core biopsy is an important additional tool in the preoperative work-up of breast masses highly suspicious for malignancy, in order to reduce the number of frozen sections.

Biopsy, Needle↗

PubMed1996

Quantitative microvessel density. A staging and prognostic marker for human prostatic carcinoma.

BACKGROUND: Accurate methods of predicting pathologic stage and malignant potential of carcinoma of the prostate are lacking. Such advances would represent major additions to our ability to recommend therapy and offer prognostic information. Quantitation of microvessel density (MVD) has been shown in a number of organ systems to predict tumor aggressiveness. METHODS: We and others have investigated this modality in preoperative assessment of pathologic stage and freedom from progression in patients with prostatic carcinoma. RESULTS: Unique and useful staging information has been provided and indeed quantitation of MVD has been shown to be a better predictor of the findings of radical prostatectomy than clinical stage, serum prostate specific antigen (PSA), and/or the Gleason score. Applying a variety of therapeutic modalities, quantitative MVD can be shown to provide additional information to predict who will or will not progress. Recent observations have demonstrated that quantitative MVD may be performed on a limited tissue sample provided by prostate core needle biopsy. CONCLUSIONS: Quantitative MVD may provide important staging and prognostic information for males with carcinoma of the prostate. The results may influence the recommendation for additional staging studies, provide stratification of patients for neoadjuvant or adjuvant therapy, assist in technical aspects of definitive therapy, and aid in defining optimum monitoring regimens.

Biopsy, Needle↗

PubMed1996

[Pseudocysts of the pancreas. Diagnosis, course and principles of treatment].

Pseudocysts of the pancreas are collections of liquid more or less completely composed of pancreatic secretions. Patients with acute pancreatitis without underlying chronic pancreatitis may develop necrotic pseudocysts while those with chronic pancreatitis may develop either necrotic or retention pseudocysts. The prevalence and localization are largely dictated by the cause of the pancreatitis. Ultrasonography and computed tomography give the diagnosis and reveal the size, localization and relations of the pseudocyst. Some pseudocysts may regress spontaneously, usually within a few weeks, especially necrotic pseudocysts measuring less than 6 cm. In others, complications include acute infection, intracystic bleeding, rupture, fistulization and compression of neighboring organs. Surgery was classically proposed for all pseudocysts, but puncture-evacuation and percutaneous or endoscopic drainage have also been successful. The risk of recurrence is higher with puncture-evacuation. Today, complicated forms and unsuccessful medical treatment are good indications for surgery. Cystodigestive drainage is preferred although exeresis may be required in specific cases.

Biopsy, Needle↗