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[Neonatal administration of 5,7-dihydroxytryptamine induces in the adult rat a decrease in paradoxical sleep restored by an intracisternal injection of fetal raphe cells].

L Glin·G Gandolfo·A McRae Degueurce·C Gottesmann
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Abstract

By a method of automatic on-line scoring of sleep-waking stages in the rat, a significant decrease of the mean circadian level of paradoxical sleep and a significant increase of light slow sleep were shown in adult animals after neonatal disruption of serotoninergic system by intracisternal injection of 100 micrograms of 5.7-dihydroxytryptamine, when compared to an aged matched sham group. The level of paradoxical sleep was restored in the neurotoxin-treated rats by an intracisternal injection of a suspension of foetal raphe neurons.

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5,7-DihydroxytryptamineAnimalsFetusMaleRaphe NucleiRatsRats, Inbred StrainsSerotoninSleep, REMEnglish AbstractJournal Article

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L Glin, G Gandolfo, A McRae Degueurce, C Gottesmann. 1986. [Neonatal administration of 5,7-dihydroxytryptamine induces in the adult rat a decrease in paradoxical sleep restored by an intracisternal injection of fetal raphe cells].. https://doi.org/10.1016/s0370-4475(86)80055-7

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