PubMed · 3810421
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1987. Burns.. https://pubmed.ncbi.nlm.nih.gov/3810421/
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BACKGROUND: Burn injuries trigger complex immune responses and gene expression changes, impacting wound healing and systemic inflammation. Understanding these changes is crucial for identifying biomarkers and therapeutic targets. METHODS: We analyzed two gene expression omnibus datasets (wound tissue [GSE8056] and blood [GSE37069]) to identify differentially expressed genes (DEGs) in burn injury samples versus controls. Immune cell proportions were assessed using CIBERSORT. Functional enrichment analyses (Gene Ontology and Kyoto Encyclopedia of Genes and Genomes) and protein-protein interaction networks were constructed to identify key genes and pathways. RESULTS: We identified 1170 upregulated and 1227 downregulated DEGs. Gene Ontology analysis revealed enrichment in neutrophil activation, inflammatory response, and extracellular matrix organization. Kyoto Encyclopedia of Genes and Genomes analysis highlighted cytokine-cytokine receptor interaction, TNF, and IL-17 signaling pathways. Immune infiltration analysis showed significant changes in neutrophils, macrophages (M1/M2), and T-cell subsets. Protein-protein interaction network analysis identified five hub genes: JUN, STAT1, Bcl2, MMP9, and TLR2. CONCLUSIONS: This study provides a comprehensive bioinformatic analysis of gene expression and immune responses in burn injuries. The identified DEGs, hub genes, and pathways offer insights into the immune response mechanisms and suggest potential targets for diagnostic and therapeutic interventions in burn injury management.
Burn injury remains one of the most devastating ordeal that a human being can sustain because of the function of the skin on vital and psychological levels. After-effects are mainly observed at cutaneous level as functional and aesthetically deformity contractures and may be linked with deeper lesions too. In most cases secondary surgical procedures are undertaken after stabilization of the inflammatory process but earlier surgery is needed in some cases because of problems encountered at ocular, mouth and neck levels mainly. All the possibilities of plastic surgery can be utilized. However in our practice Z plasties and skin grafts represent the basis of the burn reconstructive surgery while the more recent technique of tissue expansion has extended the part of local and regional flaps (but one should not use it as a routine method).
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