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Metabolites of 3-hydrazino-6-[bis-(2-hydroxyethyl)amino]pyridazine dihydrochloride in rat urine.

E Beretta·T Cristina·P Ferrari·G Tuan·L F Zerilli·E Martinelli
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Abstract

In 24 hr urine of rats orally given 150 mg/kg of 3-hydrazino-6-[bis-(2-hydroxyethyl)amino]pyridazine dihydrochloride (DL 150), no unchanged compound was detected. Three metabolites, less polar than DL 150, were isolated, their structures assigned by UV, MS, IR and 1H NMR spectroscopies, and confirmed by synthesis. They are: 3-[bis-(2-hydroxyethyl)amino]-6-isopropoxypyridazine (1); 3-[bis-(2-hydroxyethyl)amino]pyridazine (2); 3-methyl-6-[bis-(2-hydroxyethyl)amino]-s-triazolo[4,3-b]pyridazine (3). The metabolism of DL 150 in the rat follows some of the metabolic pathways reported for hydralazine.

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AnimalsAntihypertensive AgentsBiotransformationChemical PhenomenaChemistryChromatography, Thin LayerDrug StabilityEthanolaminesHydrogen-Ion ConcentrationMalePyridazinesRatsJournal Article

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E Beretta, T Cristina, P Ferrari, G Tuan, L F Zerilli, E Martinelli. 1979. Metabolites of 3-hydrazino-6-[bis-(2-hydroxyethyl)amino]pyridazine dihydrochloride in rat urine.. https://doi.org/10.1007/bf03189396

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