Sodium-sensitive glass microelectrode: modified Thomas recessed-tip configuration.

L R Pucacco; S K Corona; N W Carter

doi:10.1016/0003-2697(86)90305-2

Home/Archive/PubMed

PubMed · 3813002

Sodium-sensitive glass microelectrode: modified Thomas recessed-tip configuration.

L R Pucacco·S K Corona·N W Carter

View original source ↗Export metadata ↓

Abstract

Using a glass-membrane, sodium-sensitive microelectrode, a modified Thomas sodium-sensitive electrode has been developed. The modified Thomas electrode possesses a high sensitivity (57.9 mV/log aNa), a high selectivity (KpotNa,K less than 0.005), a relatively low electrical resistance (7.65 X 10(11) ohms), a small sensing chamber (10 microns3), and can be made in the double-barreled configuration. The modified Thomas electrode is designed to directly measure the intracellular sodium concentration of epithelial cells.

Explore related subjects

Glass Intracellular Fluid Microelectrodes Sodium Journal Article Research Support, U.S. Gov't, P.H.S.

Keep this discovery

Explore connections, maps & timelines

BibTeX RIS

L R Pucacco, S K Corona, N W Carter. 1986-11-15. Sodium-sensitive glass microelectrode: modified Thomas recessed-tip configuration.. https://doi.org/10.1016/0003-2697(86)90305-2

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2006

Ab initio molecular dynamics study of 45S5 bioactive silicate glass.

Bioglass 45S5, the prototype of bioactive melt-quenched silicate glasses, was modeled by means of Car-Parrinello molecular dynamics (CPMD) simulations. Although long-range structural properties cannot be modeled by using this ab initio approach, the accuracy of CPMD simulations is exploited here to provide insight into the short-range structure and to analyze vibrational and electronic properties of this biomaterial. Detailed structural analysis in the short-range scale provided insight into the local environment of modifier Na and Ca ions: a possible key role of these cations in organizing the glass network by connecting different chains and fragments into specific, rather flexible geometries was proposed. The individual contributions of different species to the vibrational density of states were separated and discussed, allowing the identification of specific features in the vibrational spectrum, such as those related to phosphate groups. The components of the electronic density of states were also analyzed, enabling us to identify correlations between the electronic structure and the structural properties, such as the different bonding character of Si-O bonds involving bridging or nonbridging oxygen atoms.

Glass↗

PubMed2006

Inertial suppression of protein dynamics in a binary glycerol-trehalose glass.

The traditional approach used to predict the ability of a glassy matrix to maximally preserve the activity of a protein solute is the glass transition temperature (T(g)) of the glass. Recently it has been shown that the addition of a low T(g) diluent (glycerol) can rigidify the structure of a high T(g) glassy matrix in binary glycerol-trehalose glasses. The optimal density of glycerol in trehalose minimizes the average mean square displacements of non-exchangeable protons in the glass samples. The amount of glycerol added to a trehalose glass coincides with the maximal recovery of biological activity in a separate study using similar binary glass samples. In this study, we use molecular dynamics (MD) simulations to investigate the dynamics of a hydrated protein encased in glycerol, unary trehalose and binary glycerol-trehalose glasses. We have found that we are able to reproduce the rigidification of the glycerol-trehalose glassy matrix and that there is a direct correlation between bulk glass dynamics and the extent of atomic fluctuation of protein atoms. The detailed microscopic picture that emerges is that protein dynamics are suppressed mainly by inertia of the bulk glass and to a lesser extent specific interactions at the protein-solvent interface. Thus, the inertia of the glassy matrix may be an influential factor in the determination of pharmaceutically relevant formulations.

Glass↗

PubMed2006

Bulk photochromism in a tungstate-phosphate glass: a new optical memory material?

In this work, we present a new photochromic tungstate based glass which have both absorption coefficient and refractive index modified under laser exposure. The photosensitive effect is superficial under ultraviolet (UV) irradiation but occurs in the entire volume of the glass under visible irradiation. The effect can be obtained in any specific point inside the volume using an infrared femtosecond laser. In addition, the photosensitive phenomenon can be erased by specific heat treatment. This glass can be useful to substitute actual data storage supports and is a promising material for 3-dimensional (3D) and holographic optical storage.

Glass↗