PubMed · 38165
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1979. Alcohol-drug interactions.. https://pubmed.ncbi.nlm.nih.gov/38165/
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AIMS: To further test whether the baclofen-induced suppression of motivation to consume alcohol in animals could be transposed to humans. METHODS: A patient who had neither tolerated nor benefited from other alcohol treatment modalities was put on trial with baclofen on a dosage up to 140 mg/day. RESULTS: The patient reported dramatic reduction in cravings for and preoccupation with alcohol. CONCLUSIONS: High-dose baclofen therapy was associated with complete and prolonged suppression of symptoms and consequences of alcohol-dependence.
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