A structurally abnormal insulin causing human diabetes.

H Tager; B Given; D Baldwin; M Mako; J Markese; A Rubenstein; J Olefsky; M Kobayashi; O Kolterman; R Poucher

doi:10.1038/281122a0

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A structurally abnormal insulin causing human diabetes.

H Tager·B Given·D Baldwin·M Mako·J Markese·A Rubenstein·J Olefsky·M Kobayashi·O Kolterman·R Poucher

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Abstract

Insulin isolated from the pancreas of a diabetic patient with fasting hyperinsulinaemia showed decreased activity in binding to cell membrane insulin receptors and in stimulating cellular 2-deoxyglucose transport and glucose oxidation. Chemical studies suggest that the isolated hormone is a mixture of normal insulin and an abnormal variant which contains a leucine for phenylalanine substitution at position 24 or 25 of the insulin B-chain.

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Amino Acid Sequence Diabetes Mellitus Heterozygote Humans Insulin Insulin Resistance Islets of Langerhans Mutation Receptor, Insulin Structure-Activity Relationship Case Reports Journal Article Research Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.

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H Tager, B Given, D Baldwin, M Mako, J Markese, A Rubenstein, J Olefsky, M Kobayashi, O Kolterman, R Poucher. 1979-09-13. A structurally abnormal insulin causing human diabetes.. https://doi.org/10.1038/281122a0

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