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PubMed · 3827197

[Autoimmune polyendocrinopathies. Pathogenic hypotheses].

W A Scherbaum·P Youinou·D Tater·J Jouquan·R Pujol-Borrell·J P Bercovici·G F Bottazzo
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Abstract

In most of the cases, once a given endocrine gland is involved, the corresponding specific autoantibody may be detected; for example, anti-islet cell antibodies are produced within the first few years, after onset of symptoms in insulin-dependent diabetes (DID). Accompanying autoantibodies are quite frequently found in the patient himself. In Schmidt's syndrome (thyroid and adrenal glands are involved and associated to IDD in 30% of the cases) thyroid microsomal antibodies are found in 38% of the cases, thyroglobulin antibodies in 11% of the cases, islet-cell antibodies in 7% of the cases and steroid cell antibodies in 17% of the cases. Associations are also possible in patient family members. Aberrant expression of HLA-DR molecules at the membrane of follicular thyroid cells (as of any other endocrine gland), following a viral aggression, could well account for the endocrinopathy combinations, but alternative mechanisms should be discussed.

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Antibody SpecificityAutoantibodiesAutoimmune DiseasesEndocrine GlandsEndocrine System DiseasesHLA-DR AntigensHumansImmunity, CellularEnglish AbstractJournal Article

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W A Scherbaum, P Youinou, D Tater, J Jouquan, R Pujol-Borrell, J P Bercovici, G F Bottazzo. 1986. [Autoimmune polyendocrinopathies. Pathogenic hypotheses].. https://pubmed.ncbi.nlm.nih.gov/3827197/

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