Collaborative Behavioral Teratology Study: implications, current applications and future directions.

C A Kimmel; J Buelke-Sam; J Adams

PubMed · 3835466

Collaborative Behavioral Teratology Study: implications, current applications and future directions.

Abstract

The general conclusions from the Collaborative Behavioral Teratology Study (CBTS) and the implications for research and testing in the field of behavioral teratology are discussed. The results of the CBTS indicate that behavioral teratology data are reproducible, if appropriate attention to study design and testing procedures is maintained. The statistical detection sensitivity of most of the test procedures was excellent, requiring no more than a 5-20% change from control values to detect an effect. Litter, gender and early testing experience may contribute significant variation and should be controlled in any testing situation. The application of behavioral teratology testing and the regulatory role of data for hazard assessment and risk estimation to the human population are discussed. Future research needs were identified from the CBTS workshop discussions.

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Animals Behavior, Animal Costs and Cost Analysis Female Pregnancy Prenatal Exposure Delayed Effects Reflex, Startle Research Design Risk Teratogens Journal Article

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C A Kimmel, J Buelke-Sam, J Adams. Collaborative Behavioral Teratology Study: implications, current applications and future directions.. https://pubmed.ncbi.nlm.nih.gov/3835466/

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