Experimental endocarditis and fosfomycin.

A Rodríguez; M V Vicente; T Olay

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PubMed · 3836112

Experimental endocarditis and fosfomycin.

A Rodríguez·M V Vicente·T Olay

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Abstract

The effectiveness of fosfomycin in combination with other antibiotics was studied in vitro and in the treatment of left-sided endocarditis in rabbits caused by S. sanguis, S. faecalis, S. aureus or P. aeruginosa. In vitro combinations of fosfomycin plus penicillin, fosfomycin plus cloxacillin, and fosfomycin plus amikacin were synergistic against the strains tested. In vivo synergism was also demonstrated since fosfomycin combinations produced a greater reduction in the number of CFU/g of vegetations than the administration of one antibiotic alone.

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Animals Anti-Bacterial Agents Drug Evaluation, Preclinical Drug Synergism Endocarditis, Bacterial Fosfomycin Microbial Sensitivity Tests Pseudomonas Infections Rabbits Staphylococcal Infections Stem Cells Streptococcal Infections Journal Article

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A Rodríguez, M V Vicente, T Olay. 1985. Experimental endocarditis and fosfomycin.. https://pubmed.ncbi.nlm.nih.gov/3836112/

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