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PubMed · 3838109

Prostacyclin biosynthesis and platelet function in autonomic dysfunction.

M R Goldberg·D Robertson·G A FitzGerald
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Abstract

We measured urinary excretion of the principal metabolite of prostacyclin, PGI-M (2,3-dinor-6-keto-PGF1 alpha) in two patients with Shy-Drager syndrome and three with idiopathic orthostatic hypotension. All patients had a rise in blood pressure (30 +/- 6 mm Hg) after ingestion of 50 mg indomethacin. Urinary excretion of PGI-M was normal and fell 57 +/- 11% after administration of indomethacin. In two subjects, there was no evidence of any circulating inhibitor of platelet aggregation when hypotension was induced by upright posture or ingestion of a meal. Despite the efficacy of indomethacin, these patients with autonomic dysfunction did not show increased production of the vasodilator prostanoid prostacyclin.

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6-Ketoprostaglandin F1 alphaAgedAutonomic Nervous System DiseasesFemaleHumansHypotension, OrthostaticIndomethacinMaleMiddle AgedPlatelet AggregationShy-Drager SyndromeJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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M R Goldberg, D Robertson, G A FitzGerald. 1985. Prostacyclin biosynthesis and platelet function in autonomic dysfunction.. https://doi.org/10.1212/wnl.35.1.120

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