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PubMed · 3838139

A special lipid mixture for membrane fluidization.

M Lyte·M Shinitzky
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Abstract

The potency for membrane fluidization of mixtures containing neutral lipids (NL), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) from hen egg yolk was tested on human erythrocytes and lymphocytes. A specific mixture consisting of 70% NL, 20% PC and 10% PE was found to be a potent membrane fluidizer operating almost exclusively by extracting membrane cholesterol. Spectral results and electron micrographs indicate that aqueous dispersion of this mixture consists of chylomicron-like assemblies where the neutral lipids provide the hydrophobic core on the surface of which phospholipids are spread as a monolayer.

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Drug CombinationsErythrocytesGlyceridesHumansLipidsLymphocytesMembrane FluidityMicroscopy, ElectronPhosphatidylcholinesPhosphatidylethanolaminesSpectrophotometryJournal Article

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BibTeXRIS

M Lyte, M Shinitzky. 1985-01-10. A special lipid mixture for membrane fluidization.. https://doi.org/10.1016/0005-2736(85)90530-9

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