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Clonal development from a progenitor with restricted differentiative expression in acute lymphoblastic leukemia.

A M Ferraris·L Canepa·L Massimo·G Dini·G Broccia·T Meloni·G Forteleoni·C Melani·G F Gaetani
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Abstract

Three patients with acute lymphoblastic leukemia (ALL) and heterozygous for the Mediterranean variant of glucose-6-phosphate dehydrogenase (G6PD) have been investigated with the 2-deoxyglucose-6-phosphate (2dG6P) method to determine the number and type of progenitor cells in which the disease arose. A monoclonal origin was established for the lymphoblasts, while the other hemopoietic cell lines were not involved in the leukemic process.

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ChildChild, PreschoolDeoxyglucoseFemaleGlucosephosphate DehydrogenaseHeterozygoteHumansLeukemia, LymphoidMiddle AgedNeoplastic Stem CellsStem CellsCase ReportsJournal ArticleResearch Support, Non-U.S. Gov't

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A M Ferraris, L Canepa, L Massimo, G Dini, G Broccia, T Meloni, G Forteleoni, C Melani, G F Gaetani. 1985. Clonal development from a progenitor with restricted differentiative expression in acute lymphoblastic leukemia.. https://doi.org/10.1002/ajh.2830200111

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