Human transforming growth factor-beta complementary DNA sequence and expression in normal and transformed cells.

R Derynck; J A Jarrett; E Y Chen; D H Eaton; J R Bell; R K Assoian; A B Roberts; M B Sporn; D V Goeddel

doi:10.1038/316701a0

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Human transforming growth factor-beta complementary DNA sequence and expression in normal and transformed cells.

R Derynck·J A Jarrett·E Y Chen·D H Eaton·J R Bell·R K Assoian·A B Roberts·M B Sporn·D V Goeddel

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Abstract

The partial amino-acid sequence of purified human transforming growth factor-beta (TGF-beta) was used to identify a series of cDNA clones encoding the protein. The cDNA sequence indicates that the 112-amino acid monomeric form of the natural TGF-beta homodimer is derived proteolytically from a much longer precursor polypeptide which may be secreted. TGF-beta messenger RNA is synthesized in various normal and transformed cells.

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Amino Acid Sequence Base Sequence DNA Humans Neoplasms Peptides RNA, Messenger Transforming Growth Factors Journal Article

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R Derynck, J A Jarrett, E Y Chen, D H Eaton, J R Bell, R K Assoian, A B Roberts, M B Sporn, D V Goeddel. Human transforming growth factor-beta complementary DNA sequence and expression in normal and transformed cells.. https://doi.org/10.1038/316701a0

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